Functional genomics and computational analyses in chickens provide powerful tools in order to understand the function and regulation of genes and obtaining new insight into the evolution of gene families in birds and other organisms. Since the sequencing of the genome and the development of high-throughput tools for the exploration of functional elements of the genome, the chicken has reached model organism status. Many of the features of avian biology and organization of the chicken genome make it an ideal model organism for phylogenetics and embryology, along with applications in agriculture and medicine. Although biological pathways of animals do not conform to humans perfectly, many treatment systems and drugs were developed using animal models. Īnimal models have been widely used in order to explore diseases and provide novel insights into the mechanisms of human diseases. The network analysis of the hypoxia-regulated proteins can provide new insight for a better understanding of the molecular mechanisms of the adaptation to anaerobic stress and predict roles of key proteins in human diseases. Therefore, there is no evidence for integrated response to hypoxic stress in humans. It should be noted that numerous investigations have attempted to identify candidate genes and molecular mechanisms involved in the process of adaptation to hypoxia and incidence of disorders however, this process contains complex biological regulatory pathways, leader proteins, and different gene expression patterns. In this way, cerebral anoxia induces the neuron cell death and apoptosis, which will lead to hypoxic brain injury including Alzheimer, Huntington, and Parkinson. Therefore, any alteration or dysfunction in mitochondrial activity can lead to irreparable injuries of the body’s organs, especially in the central nervous system, because the brain is considered as the most sensitive organ to the consumption of oxygen and energy. The lack of normal oxygen level leads to the inadequate mitochondrial metabolism, and also plays a critical role in cell survival. In addition, the low oxygen concentration in high-altitude conditions is another risk factor for diseases. As an example, in high-altitude conditions, high doses of UV (ultraviolet) radiation lead to the DNA damage, cell apoptosis, skin cancer, and tissue injuries in mammals. Many studies aimed to explain the role of hypoxia in diseases and disorders. It has been demonstrated that there is close association between abnormal level of oxygen and human’s disorders and hypoxia is known as the common symptom among human diseases such as cancers, cardiovascular, heart failure, ischemia, cerebral edema, and diabetes. Thus, organisms must adapt to the low oxygen environment to increase the chance of survival. Hypoxia refers to the condition of low oxygen pressure in atmosphere, and is also considered as one of the most important factors that can impact on many biological pathways of cells. Furthermore, we suggested, UV radiation and low oxygen conditions in high-altitude regions may be responsible for the variety of human diseases. Our results showed that hypoxia-associated genes were enriched in several gene networks of disorders including Parkinson, Alzheimer, cardiomyopathy, drug toxicity, and different types of cancers. ![]() Our results suggested DNA damages caused by the high doses of UV radiation in high-altitude conditions, were associated with breast cancer, ovarian cancer, and colorectal cancer. Dexamethasone was reported as the candidate toxic drug under the hypoxia condition that implicates diabetes, osteoporosis, and neurotoxicity. Furthermore, calmodulin, and amyloid precursor protein were detected as leader proteins in Alzheimer’s diseases. Lewy body and neuromelanin were reported as key symptoms in Parkinson disease. We found that biological pathways are involved in mitochondrion dysfunctions including peroxynitrous acid production denoted in brain injuries. It was found that hypoxia-associated genes contained several gene networks of disorders such as Parkinson, Alzheimer, cardiomyopathy, drug toxicity, and cancers. ![]() The main goal of this study was to visualize the features of diseases due to hypoxia-associated genes by gene network analysis. Based on our previous findings, we used chicken as a model and the identified hypoxia-associated genes were converted to human’s orthologs genes to construct the informative gene network. Previously, we carried out a comparative genomic study by whole genome resequencing of highland and lowland Iranian native chickens to identify genomic variants associated with hypoxia conditions. Hypoxia refers to the condition of low oxygen pressure in the atmosphere and characterization of response to hypoxia as a biological complex puzzle, is challenging.
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The band has had several hit singles including “Don’t Know What You’ve Got Until It’s Gone,” “Somebody Save Me,” “Heartbreak Station,” “Nobody’s Fool,” “The Last Mile,” & “Shake Me.”Īdditionally, he has also played in bands such as the Naked Beggars, Freakshow, Cheap Thrill and also fronted a solo project since 2014. The band has sold over 15 million records worldwide. In addition to appearing on all four of the band’s albums, he also appears on their two greatest hits compilation cds and their live project, Live At The Key Club. LaBar has appeared on all four of Cinderella’s albums, including Night Songs, Long Cold Winter, Heartbreak Station and their final album, Still Climbing. Frontman Tom Keifer stated in November 2017 that the popular rock group has no plans to reunite, explaining that “issues between the band members are beyond repair.” Cinderella formed in 1982 in the suburbs of Philadelphia and in 2017 the band broke up. RIP tributes and prayers, please kindly scroll down and use the comment box to share your feelings about the heartbreaking news.A post shared by Sebastian LaBar Pennsylvania native and guitarist has previously admitted to struggling with alcoholism for years and even blame the substance abuse for Cinderella’s inactivity. Thank you for all the music!! Shred in peace! Texas – San Antonio”Īn online user wrote on Twitter: “I just heard, there goes another piece of my childhood. He was reportedly found dead on Wednesday, July 14 inside his apartment in Nashville, Tennessee. I love you pop A cause of death was not immediately disclosed. Jeff LaBar, best known as the guitarist for the glam metal band Cinderella, died at the age of 58. His son, Tantric guitarist Sebastian LaBar, described him in an Instagram post as my father, my hero, my idol. Rest In Peace.”Īnother wrote: “Gone way too soon at the young age of 58 Guitarist of 89’s band Cinderella. Jeff LaBar, lead guitarist with glam metal band Cinderella, died Wednesday at 58. Absolutely heartbreaking….We will miss you, Jeff. In his honor, I will be playing Cinderella whenever I want to listen to music for at least the next several days. One of his fans tweeted: “Just now found out about Jeff Labar’s passing. The bond between us over decades of creating music and touring the world is something that we as a band uniquely shared.” Welcome to the Official Page of Jeff LaBar guitarist of Cinderella - accept no substitutes Jeff Labar. Surviving Cinderella members Fred Coury, Keifer, and Eric Brittingham released a statement saying, “Heavy hearts cannot begin to describe the feeling of losing our brother Jeff. ![]() ![]() You can read about other celebrities’ life and career till death in the celebrity death section.įollowing the tragic news, several fans, friends, and supporters reacted and stated their condolences on social media websites. He wrote all the songs and played all the instruments, with the exception of drums on “ Road For the Road.” It would crack the Billboard 200, topping out at No.130. Jeff worked on a handful of side projects, including Naked Beggars and Cheap Thrill, and dropped his own debut solo EP, One for the Road, in 2014. CINDERELLA guitarist Jeff LaBar was found dead at his Nashville apartment on Wednesday. The cause of death has yet been revealed. LaBar’s son, Sebastian, and his father, Bob, confirmed the news in separate social media. Jeff LaBar, lead guitarist with glam metal band Cinderella, died Wednesday at 58. Although Cinderella would reunite for several live performances in the 2000s, Still Climbing would mark its last release. glam metal outfit Cinderella, died Wednesday (July 14), at the age of 58. Jeff LaBar, best known as the guitarist for Philadelphia area glam metal band Cinderella, has died. ![]() The band went on a break following the studio album Still Climbing in 1994. The group also impacted the Billboard 200 chart with all four titles, including: It’s no secret that I’ve had a drinking problem.” ![]() Once Labar said blamed himself for the break up of Cinderella, revealing on an installment of the Another FN Podcast With Izzy Presley in 2016: “I believe it’s all my fault. They released their next album, “Long Cold Winter,” in 1988 and released their signature song: “ Don’t Know What You Got Till It’s Gone.” The band released its debut album “Night Songs” in 1986, which jumped to the third slot on the Billboard 200. |